| 摘要 |
PURPOSE: To diminish adverse effects caused by a high dose of racemic mixture of isoflurane or desflurane which is an anesthetic for inducing and maintaining anesthesia and which is administered by inhalation. CONSTITUTION: This method of inducing and maintaining anesthesia comprises administering by inhalation to a warm blooded animal including a mammal in need of anesthesia an amount sufficient to induce and maintain anesthesia but insufficient to cause adverse effects, of (S)-isoflurane or (S)-desflurane substantially not containing (R)-stereoisomer, while diminishing the concomitant liability of adverse effects, such as hypoventilation, low blood pressure and arrhythmia, associated with the administration. The inhalation concentration of the anesthetic (S-isomer) administered for inducing the anesthesia is 0.5-5.0%, 0.5-2.5%, when nitrous oxide is simultaneously administered, or 0.5-3.5%, when oxygen is simultaneously administered. Since the (S)-isoflurane or (S)-desflurane exhibits the anesthetic activity in a lower concentration and at a lower dose than the corresponding racemic mixture, adverse effects are little.
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