| 摘要 |
4-18942/A/CGC 1599 BIARYL SUBSTITUTED 4- AMINO-BUTYRIC ACID AMIDES The invendon relates to biaryl subsdtuted 4-amino-butyric acid derivatives of formula I (I) wherein COX and COX' independently represent carboxyl or carboxyl derivatized in form of a pharmaceutdcally acceptable ester or amide; R1 represents hydrogen, lower alkyl, C3-C7-cycloalkyl-lower alkyl, aryl-lower alkyl, biaryl-lower alkyl, lower alkoxy, aryl-lower alkoxy, aryloxy, N-lower alkylamino, N,N-di-lower alkylamino, N-aryl-lower alkylamino, N,N-di-aryl-lower alkylamino, N-arylamino, N,N-diarylamino, lower alkanoylamino, aryl-lower alkanoylamino or aroylamino; R2 represents hydrogen, hydroxy, lower alkoxy, lower alkyl, aryl-lower alkyl, C3-C7-cycoalkyl-lower alkyl, amino-lower alkyl, hydroxy-lower alkyl, lower alkylthio-lower alkyl, lower alkoxy-lower alkyl, aryl-lower alkylthio-lower alkyl or aryl-lower alkoxy-lower alkyl; biaryl represents phenyl substdtuted by carbocyclic or heterocyclic aryl; A represents a direct bond, lower alkylene, phenylene or cyclohexylene; m represents 1 or zero, provided that m represents 1 when A is a direct bond; or pharmaceudcally acceptable salts thereof; pharmaceutical compositions comprising said compounds; methods for the preparadon of said compounds and for the preparadon of intermediates; and methods of treatdng disorders in mammals which are responsive to the inhibitioon of neutral endopeptidases by administradon of said compounds to mammals in need of such treatment.
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