PHARMACEUTICAL COMPOSITIONS CONTAINING POLYMER DERIVATIVE-BOUND ANTHRACYCLINE GLYCOSIDES AND A METHOD FOR THEIR PREPARATION

摘要

A lyophilized composition comprising (a) a conjugate comprising an N-alkyl methacrylamide-based copolymer and an anthracycline glycoside linked through a peptide spacer to the copolymer and (b) a cosolubilizing agent may optionally also contain (c) a filler. Also optionally, a targeting moiety may be linked to the copolymer of the conjugate via a peptide spacer. An injectable solution of the conjugate is obtained by reconstitution of the lyophilized composition.