发明名称 |
INACTIVATION OF CYTOTOXIC DRUGS |
摘要 |
A three component kit of parts for use in a method of destroying target cells in a host is provided. The first component comprises a target cell-specific portion and an enzymatically active portion capable of converting a cytotoxic pro-drug into a cytotoxic drug. The second component is a cytotoxic pro-drug convertible by said enzymatically active portion to the cytotoxic drug. The third component comprises a portion capable of at least partly restraining the component from leaving the vascular compartment of a host when said compound is administered to the vascular compartment, and an inactivating portion capable of converting the cytotoxic drug into a less toxic substance. |
申请公布号 |
WO9313806(A1) |
申请公布日期 |
1993.07.22 |
申请号 |
WO1993GB00040 |
申请日期 |
1993.01.11 |
申请人 |
BAGSHAWE, KENNETH, DAWSON |
发明人 |
BAGSHAWE, KENNETH, DAWSON |
分类号 |
A61K9/08;A61K31/195;A61K31/505;A61K35/18;A61K38/45;A61K38/46;A61K39/395;A61K47/48;A61P35/00;A61P43/00 |
主分类号 |
A61K9/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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