Antigen and antibody vaccine compositions effective in preventing hepatitis E virus (HEV) infection are disclosed. The antigen composition includes a peptide corresponding to a carboxyl terminal end region of the capsid protein encoded by the second open reading frame (2) of the HEV genome. The composition is effective in preventing HEV infection after vaccination. The antibody composition contains an antibody effective to block HEV infection of human primary hepatocytes in culture.
申请公布号
WO9314208(A2)
申请公布日期
1993.07.22
申请号
WO1993US00475
申请日期
1993.01.19
申请人
GENELABS TECHNOLOGIES, INC.;THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS