PIPERIDINEACETIC ACID DERIVATIVES AS INHIBITORS OF FIBRINOGEN-DEPENDENT BLOOD PLATELET AGGREGATION

摘要

The invention relates to acetic acid derivatives of formula (I) and pharmaceutically acceptable derivatives thereof and salts and solvates thereof, where: X?1 and Y1¿, which may be the same or different, represent CH or N; X2 represents CH or, when X1 represents CH, may also represent N; Y2 represents N or, when Y1 represents N, may also represent CH; Z represents N or N+R5; R1 represents a hydrogen atom or a hydroxyl, C¿1-4?alkyl or 2,2,2-trifluoroethyl group; R?2¿ represents a hydrogen atom or, when both X?1 and X2¿ represent CH, may also represent a fluorine, chlorine or bromine atom or a C¿1-4?alkyl group; R?3¿ represents a hydrogen atom or, when both Y?1 and Y2¿ represent N, may also represent a C¿1-4?alkyl or hydroxymethyl group; R?4¿ represents a hydrogen atom or, when Z represents N, R4 may also represent a C¿1-4?alkyl group; R?5¿ represents a C¿1-4?alkyl or phenylC1-4alkyl group; R?6¿ represents a naphthyl group; a thiophenyl group; an unsubstituted phenyl group; a phenyl group substituted by C¿1-4?alkyl, C1-4alkoxy, phenylC1-3alkoxy, OH, halogen, where halogen is fluorine, chlorine, bromine or iodine, CF3, unsubstituted phenyl, phenyl substituted by OH, pyridinyl, NR?7R8¿, NHSO¿2?R?7, CONR7R8¿ or CO¿2R?7; a C¿1-4?alkyl group substituted by one or more naphthyl, phenyl, OH or CO2R?7¿; a C¿2-4?alkenyl group substituted by one or more naphthyl, phenyl, OH or CO2R?7¿; or a saturated or unsaturated C¿5-7?cycloalkyl group; and R?7 and R8¿, which may be the same or different represent H or C¿1-4?alkyl or, together with the nitrogen atom to which they are attached, form a saturated 5 to 7 membered ring. The compounds inhibit fibrinogen dependent blood platelet aggregation.