VERFAHREN ZUR HERSTELLUNG VON CEFODIZIM.

摘要

Prodn. of cefodizin (I) is effected by (a) reacting a 2-(2-amino -4-thiazolyl)-2-methoxyimino -acetic acid cpd. of formula (II) with a sulphonyl halide of formula (III) in an organic solvent, opt. in the presence of a base; (b) reacting a 7-amino-3-cephen -4-carboxylic acid deriv. of formula (IV) with a silylating agent in an organic solvent, opt. in the presence of a base: (c) reacting together the solns. from (a) and (b); and (d) removing any protecting gps. R1 = H or a protecting gp.: A = H, alkali(ne earth) metal, NH4 or an organic N-contg. base: R = opt. substd. alkyl, aryl or aralkyl; X = halogen.