A HUMAN KUNITZ-TYPE PROTEASE INHIBITOR VARIANT

摘要

Variant of human Kunitz-type protease inhibitor domain II of tissue factor pathway inhibitor (TFPI), the variant comprising the following amino acid sequence X<1> Asp Phe Cys Phe Leu Glu Glu Asp X<2> Gly X<3> Cys X<4> X<5> X<6> X<7> X<8> X<9> Tyr Phe Tyr Asn Asn Gln Thr Lys Gln Cys Glu Arg Phe X<10> Tyr Gly Gly Cys X<11> X<12> X<13> Met Asn Asn Phe X<14> Thr Leu Glu Glu Cys Lys Asn Ile Cys Glu Asp X<15> (SEQ ID No. 1), wherein X<1> represents H or 1-5 naturally occurring amino acid residues except Cys, X<2>-X<14> each independently represents a naturally occurring amino acid residue, and X<15> represents OH or 1-5 naturally occurring amino acid residues except Cys, with the proviso that at least one of the amino acid residues X<1>-X<15> is different from the corresponding amino acid residue of the native sequence.