| 摘要 |
Compounds of the general formula I <IMAGE> wherein R1 represents a halophenyl, dihalophenyl, nitrophenyl, cyanophenyl or trifluoromethylphenyl group; X represents a single bond, -CH2-, -OCH2-, SCH2, -S(O)-CH2-, -S(O)2-CH2- or -CH2CH2- R2 represents hydrogen or C1-3 alkyl; R3 represents a phenyl group substituted in the meta-position by a radical containing an organic base, an organic acid or a quaternary ammonium salt and optionally further substituted. R4 and R5 which may be the same or different each represents a C3-5 alkenyl, C3-5alkynyl, C1-6alkyl, or C4-7cycloalkylalkyl group, or together with the intervening nitrogen atom represents a 4-7 membered heterocyclic ring, and the pharmaceutically acceptable salts thereof are useful for the treatment of hypertension and/or inflammation in the warm-blooded animals. Also disclosed are processes for their preparation and pharmaceutical compositions containing them.
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