发明名称 Potential anticancer agents derived from acridine
摘要 The compounds of the subject invention can be represented as follows: <IMAGE> wherein each of R1, R2, R3, R4, are the same or different and are hydrogen (H), or a lower alkyl group of from about 1-4 carbon atoms, or a lower alkoxy group of from about 1-4 carbon atoms. R is a substituted aniline <IMAGE> wherein one of R5, R6, R7 is an alkanol having the formula -(CH2)nOH, n=1-4, or its carbamate ester having the formula -(CH2)nOCONR'R'', n=1-4, and wherein R' and R'' the same or different lower alkyl groups of from about 1 to 4 carbon atoms, one of R' and R'' may be hydrogen (H), and the remaining groups are hydrogen. Additionally, the subject invention provides methods for synthesizing the above-identified compounds, physiologically acceptable compositions containing these compounds and methods for using these compounds to inhibit the growth of tumor cells.
申请公布号 US5229395(A) 申请公布日期 1993.07.20
申请号 US19910754283 申请日期 1991.08.30
申请人 SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH 发明人 WATANABE, KYOICHI A.;TAKAHASHI, KIYOBUMI
分类号 C07C229/58;C07D219/04;C07D219/06;C07D219/10;C07D295/192 主分类号 C07C229/58
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