发明名称 |
Gene encoding one step cephalosporin C amidase and expression thereof in recombinant bacillus |
摘要 |
A process for the one-step conversion of cephalosporin C and derivatives thereof to the corresponding 7-aminocephalosporanic acid and derivatives comprising treating said cephalosporin C and derivatives with a cephalosporin C amidase enzyme of a recited sequence, the DNA encoding said enzyme, and expression thereof in a suitable host, e.g., Bacillus species under the control of a suitable promoter.
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申请公布号 |
US5229274(A) |
申请公布日期 |
1993.07.20 |
申请号 |
US19920819717 |
申请日期 |
1992.01.13 |
申请人 |
MERCK & CO., INC. |
发明人 |
CRAWFORD, MARK S.;FINKELSTEIN, DAVID B.;RAMBOSEK, JOHN A. |
分类号 |
C12N1/21;C12N9/80;C12N15/55;C12P35/02 |
主分类号 |
C12N1/21 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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