| 摘要 |
PURPOSE:To obtain the subject compound extremely reduced in the leakage of contents by encapsulating a hydrophilic substance in the inner aqueous phase of a polymerizable lipid microsome, polymerizing the lipid constituting the membrane of the microsome, adding a specific saccharide only to the removable outer aqueous phase of the microsome and subsequently lyophilizing the microsome. CONSTITUTION:The membrane component of a polymerizable lipid (e.g. polymerizable phospholipid or polymerizable glucolipid) constituting a microsome containing a hydrophilic substance such as protein, physiologically active peptide, anticancer agent, antibiotic, vitamin, immubopotentiating agent or hormone is polymerized. A saccharide (e.g. sucrose, trehalose or cellobiose) having a mol.wt. of <=1200 is added to the outer aqueous phase of the microsome. The aqueous dispersion of the microsome is lyophilized to obtain a powdery lipid microsome preparation. The preparation is extremely reduced in the leakage of the content from the inner aqueous layer of the lipid microsome, is free from the change in the particle diameter of the lipid microsome and permits to remove the saccharide added as a protecting agent, when again dispersed. |
