发明名称 |
Composite antibodies of human subgroup IV light chain capable of binding to tag-72 |
摘要 |
<p>2121041 9312231 PCTABS00023 This invention concerns a subset of composite Hum4 VL, VH.alpha.TAG antibody with high affinities to a high molecular weight, tumor-associated sialylated glycoprotein antigen (TAG-72) of human origin. These antibodies have variable regions with (1) VL segments derived from the human subgroup IV germline gene and (2) a VH segment which is capable of combining with the VL to form a three dimensional structure having the ability to bind TAG-72. in vivo methods of treatment and diagnostic assay using these composite antibodies is also disclosed.</p> |
申请公布号 |
AU9058291(A) |
申请公布日期 |
1993.07.19 |
申请号 |
AU19910090582 |
申请日期 |
1991.12.13 |
申请人 |
DOW CHEMICAL (AUSTRALIA) LIMITED |
发明人 |
PETER S. MEZES;RUTH A. RICHARD;KIM S. JOHNSON |
分类号 |
G01N33/53;A61K38/00;A61K39/395;A61K47/48;A61K51/00;A61K51/10;A61P35/00;C07K14/52;C07K14/555;C07K16/00;C07K16/18;C07K16/30;C07K16/46;C07K19/00;C12N1/21;C12N15/09;C12P21/08;C12R1/19;G01N33/531;G01N33/574;(IPC1-7):C12N15/13;A61K43/00;A61K49/02;C12N5/10 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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