| 摘要 |
PURPOSE:To reduce the blood coagulation time by arranging a non-enzyme activator as XIIth blood coagulation factor, a protease for hydroanalyzing the bond of Arg or Lys residual group with an amino residual group and a coagulating agent. CONSTITUTION:The XIIth blood coagulation factor employs a compound of the formula I (wherein A represents a residual group of a cyclic compound), for example, elaiden oxide II as given by the formula II and 1,2,3-triketohydrindene as given by the formula III as non-enzyme activator. For example, trypsin, thrombin and snake-poison thrombin enzyme are used as protease to hydroanalyze the bond of Arg or Lys residual group with any amino residual group. As this blood coagulation promotor contains the compound of the formula I and the protease, the XII factor can be activated quickly to reduce the blood coagulation time and thus, it is used effectively for clinical examination and stanching because of excellence in the separability between serum and clot. |
