摘要 |
<p>The invention relates to alpha-substituted pyridazinoquinoline compounds of the formula I: <CHEM> wherein Ring A is chosen from an ortho fused aromatic or heteroaromatic five- or six-membered ring; R<1> is selected from a variety of substituents including halogen, (1-4C)alkyl and nitro; R<2> is selected from a group of the formula R2', R2'' or R2''' wherein R2' is -CHR<3)<CH2)nC(O)NR<5>R<6>; R2'' is -CHR<3)<CH2)nR<4> and R2''', is -CHR3(CH2)nL wherein n is 0-6; R<5> is aryl or substituted aryl; R<6> is (1-6C)alkyl or hydrogen; R<3> is (1-6C)alkyl, (0-6C)alkylCF3 or (0-6C)alkylCOOR'; R<4> is (1-6C)alkyl, (2-6C)alkyl containing a double or triple bond, or (0-6C)alkylaryl; L is a variety of substituents including phenyl, heteroaryl and CO2R'; R' is hydrogen or (1-4C)alkyl; Z is selected from oxo, -OH, H,H-, H, (1-6C)alkyl or (1-6C)alkylaryl; and R<7> is hydrogen or -(CO)R<8> wherein R<8> is a variety of substituents including hydrogen and (1-12C) alkyl.</p> |