| 摘要 |
The present invention relates to a process for the preparation of aryl (or heteroaryl) piperazinyl-butylazole derivatives corresponding to the general formula I <IMAGE> (I) in which Ar denotes a nitrogenous or other aromatic radical chosen from differently substituted aryls, differently substituted 2-pyrimidine, 2-N-methyl-imidazole and 3-(1,2-benzisothiazole) Z1 denotes a nitrogen atom or an optionally substituted carbon atom which may be denoted by: C-R1 Z2 denotes a nitrogen atom or an optionally substituted carbon atom which may be denoted by: C-R2 Z4 denotes a nitrogen atom or an optionally substituted carbon atom which may be denoted by: C-R4 and R1, R2, R3 and R4, which are identical or different and may also form a part of another ring, aromatic or otherwise, denote a hydrogen atom, a halogen, a lower alkyl radical, a nitro radical, a hydroxyl radical, an alkoxy radical, a cyano radical, a carboxylic radical, a carboxamido radical, an alkylcarboxylate radical, an aryl or substituted aryl radical, a sulfonic radical, a sulfonamido radical optionally substituted on the amino group or an amino or substituted amino radical wherein <IMAGE> (IX) in which Ar has the meanings referred to above and X denotes a halogen atom, is reacted with a compound of general formula III <IMAGE> (III) in which Z1, Z2, Z4 and R3 have the meanings referred to above.
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