| 摘要 |
29 Process for preparing optically active cis-3-hydroxy-2,3-dihydro-1,5-benzothiazepin-4(5H)-one compounds ¢I! of the formula: ¢I! wherein Ring A and Ring B are substituted or unsubstituted benzene, R1 is hydrogen or di-lower alkylaminoalkyl, which comprises subjecting 1,5-benzothiazepin-4(5H)-one (II) of the formula (II): ¢II! wherein R4 is hydrogen or lower alkanoyl, and the other symbols are the same as defined above, to asymmetric reduction with a reaction product of optically active .alpha.-amino acid and metal hydride, in high optically yield, and said compounds ¢I! are very important as intermediate for preparing various medicines.
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