| 摘要 |
PURPOSE:To provide a novel compound useful as an anthelminthic. CONSTITUTION:A cyclic depsipeptide PF1022B of the formula. The substance is obtained by a PF-1022B substance-producing microorganism in an aconidial imperfect fungus is aerobically cultured in a medium containing the nutrients which can be utilized by usual microorganisms, particularly by the submerged culture method and by extracting with solvents. The descriptions of the compound are as follows: color and properties: colorless powder; melting point: 83 to 85 deg.C; molecular formula: C64H84N4O12; elementary analyses: C 69.81%, H 7.64%, N 5.09% (calculated); specific rotation: [alpha]D25=-66 deg. (c=1.0 in MeOH); solubility: soluble in chloroform, acetone, ethyl acetate, methanol, dimethyl sulfoxide; insoluble in water; acidic, basic or neutral classification: neutral one. |
