发明名称 |
USE OF POLYAMINES AS IONIC-CHANNEL REGULATING AGENTS |
摘要 |
Methods for regulating cation transport across cellular membranes possessing cation channels are provided. The cell membrane possessing a specific ion channel is exposed to a non-aromatic polyamine compound having a lysine- or arginine-based moiety (or a guanidine moiety) coupled to a straight chain polyamine. These polyamines as well as a method for regulating NMDA through a spermidine-like effect on NMDA receptors by exposing a cell membrane to selected polyamines are also provided. |
申请公布号 |
WO9312777(A1) |
申请公布日期 |
1993.07.08 |
申请号 |
WO1992US11352 |
申请日期 |
1992.12.31 |
申请人 |
NEW YORK UNIVERSITY |
发明人 |
CHERKSEY, BRUCE, D.;LLINAS, RODOLFO, R.;SUGIMORI, MUTSUYUKI |
分类号 |
A61K31/13;A61K31/155;A61K31/16;A61K38/00;C07C211/14;C07C237/10;C07C239/16;C07C279/12;C07C279/14;C07K4/12;C07K14/705 |
主分类号 |
A61K31/13 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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