GASTRIC ACID SECRETION-INHIBITING, AND GASTROCYTOPROTECTIVE PHARMACEUTICAL COMPOSITIONS, NOVEL FAMOTIDINE SALTS AND PROCESS FOR PREPARING SAME

摘要

The invention relates to a novel gastric acid secretion-inhibiting and gastrocytoprotective pharmaceutical composition, which comprises as active ingredient a 10:1 to 1:10 mixture by weight of a compound of formula (II), wherein A means a group of formula (A1), wherein R stands for a hydrogen atom or a hydroxy, C1-4alkyl or alkoxy group; X means oxygen or sulfur or NH group; or A means a group of formula (A2), wherein Q stands for a hydrogen atom or a phenyl or substituted phenyl group; m is 0 or 1; n is 0, 1 or 2; p is 1 when the dotted line represents a chemical bond, or p is 2 when the dotted line means no chemical bond; or A means a group of formula (A3), wherein R<1> means methyl, phenyl, substituted phenyl, C-4-alkyl, C1-4alkoxy or tetrahydronaphthyl group with the compound of formula (III) or a new compound of formula (I), wherein A is as defined above and B<+> represents the protonated form of the compound of formula (III). The invention furthermore relates to the novel compounds of formula (I), wherein A and B<+> are as defined above, and a process for preparing these novel compounds. The compounds of formula (I) and the compositions according to the invention are useful for curing and/or preventing the inflammatory and ulcerative diseases of esophagus, stomach and duodenum of mammal.