NEUROBLASTOMA-ASSOCIATED REGULATOR GENE

摘要

2117293 9313205 PCTABS00024 Described is a gene situated in the region of the neuroblastoma consensus deletion 1p36.2-p36.1 and which codes for a helix-loop-helix protein with the designation HEIR-1. The gene is affected significantly by allelic tumour deletions in neuroblastomas and correlates inversely both with N-myc overexpression in tumours and with N-myc expression in normal development. The cDNA and antibodies coding for HEIR-1 are used for the diagnosis of pathological conditions associated with aberrations in the region of the neuroblastoma consensus deletion.