STEM CELL INHIBITING PROTEINS

摘要

Proteinaceous molecules with stem cell inhibition activity are analogues of LD78 or MIP-1 alpha which have mutations to prevent or reduce multimer formation beyond certain stages (for example a dodecamer). Aggregate formation is therefore inhibited, and the resulting low molecular weight monomers (or oligomers) have improved solution properties leading to enhanced productivity and greater therapeutic utility as stem cell protective agents, which are useful in tumour therapy.