ENDOTHELIN-ANTAGONIZING PEPTIDE

摘要

A novel peptide represented by the following general formula and a process for producing the same: X-A-Trp-B-Gly-Thr-E-G-Y wherein, A represents Asn or Asp; B represents His or Lys; E represents Ala or Ser; G represents Ala or Pro; X represents X<1>-Gly or X<3>-Cys-X<2>; and Y represents hydroxy, lower alkoxy, amino, Y<1>-Asp-Z or Y<2>-Cys-Z. The peptide is isolated from the product of culture of a streptomyces and has an endothelin antagonism and an activity of suppressing the rise of an intracellular calcium or cyclic guanosine-3,5-phosphate concentration caused by endothelin.