摘要 |
This invention provides novel compounds of formula (I) wherein Y is -CH2- or -CO-; R1 is F, Cl or OH; R2 is H, F or Cl; and R3 is H, CH3 or CH2CH3, excluding 4-(5-chloro-2,3-dihydro-1H-inden-2-yl)-1H-imidazole and 4-(4-chloro-2,3-dihydro-1H-inden-2-yl)-1H-imidazole and their non-toxic acid addition salts and mixtures thereof. Processes for the preparation of these compounds are described, as are novel pharmaceutical compositions comprising at least one of the compounds or their salts. The compounds and their non-toxic salts exhibit valuable pharmacological activity and are highly selective and long acting antagonists at a2-adrenoceptors. Their peroral bioavailability is good. The compounds are especially useful in the treatment of cognitive disorders. |
申请人 |
ORION-YHTYMAE OY |
发明人 |
KARJALAINEN, ARTO, JOHANNES;VIRTANEN, RAIMO, EINARI;KARJALAINEN, ARJA, LEENA;ELORANTA, MAIRE, MARJATTA;SALONEN, JARMO, SAKARI;SIPILAE, HANNU, TAPANI;HAAPALINNA, ANTTI, SAKARI |