发明名称 |
PROTEIN- AND PEPTIDE-METAL ION PHARMACEUTICAL APPLICATIONS |
摘要 |
Peptides containing a biological-function domain and a medically useful metal ion-binding domain and proteins containing monosulfide or disulfide bonds are labeled with medically useful metal ions for use in diagnosis and treatment of a variety of pathologic conditions. The peptides have the amino acid sequence (R1)-[Y1]n-(R2), (R1)-[Y1-(R2)-Y1]n-(R3), and (R1)-[Y1-(R2)-Y2]n-(R3), with the biological-function domain optionally containing the sequence IKVAV and YIGSR. The medically useful metal ion-binding domain is [Y1]n, [Y1-(R2)-Y1]n or [Y1-(R2)-Y2]n. Sn(II) agents are used to label the proteins with medically useful metal ions. |
申请公布号 |
WO9312819(A1) |
申请公布日期 |
1993.07.08 |
申请号 |
WO1992US11334 |
申请日期 |
1992.12.31 |
申请人 |
RHOMED INCORPORATED |
发明人 |
RHODES, BUCK, A.;ZAMORA, PAUL, O. |
分类号 |
A61K38/00;A61K49/08;A61K51/08;A61K51/10;C07K5/083;C07K7/06;C07K7/08;C07K14/52;C07K14/655;C07K14/78 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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