发明名称 Sustained release suppositories and a process for preparation.
摘要 <p>A sustained release suppository comprising in a usual suppository base a) a water-soluble therapeutically active substance, the average particle size of which is smaller than 20 mu m, b) a physiologically acceptable organic substance which is swellable in contact with water, and c) hydrophobic silicium dioxide. The suppository base is usually a fat having a melting range of from 29 to 38 DEG C. As ingredient b) cellulose derivatives such as hydroxypropylmethylcellulose may be used, in a quantity of from 5 to 40% by weight, preferably 9 to 15% by weight. Ingredient c) is preferably used in a quantity of from 3 to 6% by weight. Also a process for manufacturing the suppositories is described. <IMAGE></p>
申请公布号 EP0550100(A1) 申请公布日期 1993.07.07
申请号 EP19920203989 申请日期 1992.12.17
申请人 DAGRA PHARMA B.V. 发明人 JAUW, TJOE HANG;FRIJLINK, HENDRIK WILLEM;MOOLENAAR, FRITS;MEIJLINK, PETER
分类号 A61J3/08;A61K9/02;A61K31/485 主分类号 A61J3/08
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