发明名称 |
Method of preparing (+)-deoxoartemisinin and selected analogues of (+)-deoxoartemisinin |
摘要 |
This invention is a new method for preparing compounds useful as antimalarial agents having the formula; <IMAGE> wherein R is hydrogen, a linear, branched or cyclo lower alkyl group having 1 to 8 carbon atoms; aminoalkyl; branched aminoalkyl; hydroxyalkyl: alkylcarboxylate or alkylbenzoate groups having 1 to 5 carbon atoms in the alkyl chains; aryl; alkoxy-substituted aryl; heteroaryl; and pyridinium groups. The method comprises treating artemisinic acid with a methylating agent followed by a stereoselective reduction of the methylated compound, subjecting the reduced compound to a Grignard addition followed by chiral photoxidation with subsequent treatment with a cyclization agent.
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申请公布号 |
US5225562(A) |
申请公布日期 |
1993.07.06 |
申请号 |
US19900565470 |
申请日期 |
1990.08.10 |
申请人 |
MCCHESNEY, JAMES D.;JUNG, MANKIL |
发明人 |
MCCHESNEY, JAMES D.;JUNG, MANKIL |
分类号 |
C07D493/20 |
主分类号 |
C07D493/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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