发明名称 |
1,2-dehydrogenation of steroidal 21-esters with Arthrobacter simplex or Bacterium cyclooxydans |
摘要 |
The present invention involves processes for 1,2-dehydrogenation of DELTA 4-3-keto C21-hemiester steroids of formula (I) <IMAGE> (I) with Arthrobacter simplex or Bacterium cyclooxydans to produce the corresponding DELTA 1,4-3-keto C21 hemiester of formula (II) <IMAGE> (II) or free alcohol thereof with improved yields. The advantage is that the processes utilize higher substrate concentrations and give shorter reaction times than previously were known.
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申请公布号 |
US5225335(A) |
申请公布日期 |
1993.07.06 |
申请号 |
US19890582954 |
申请日期 |
1989.09.12 |
申请人 |
THE UPJOHN COMPANY |
发明人 |
KOMINEK, LEO A.;WOLF, HOLLY J.;STEIERT, PAULA S. |
分类号 |
C07J5/00;C07J13/00;C12P33/02 |
主分类号 |
C07J5/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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