GENES IDENTIFIED AS REQUIRED FOR PROLIFERATION IN ESCHERICHIA COLI
摘要
The sequences of nucleic acids encoding proteins required for E. coli proliferation are disclosed. The nucleic acids can be used to express proteins or portions thereof, to obtain antibodies capable of specifically binding to the expressed proteins, and to use those expressed proteins as a screen to isolate candidate molecules for rational drug discovery programs. The nucleic acids can also be used to screen for homologous genes that are required for proliferation in microorganisms other than E. coli. The nucleic acids can also be used to design expression vectors and secretion vectors. The nucleic acids of the present invention can also be used in various assay systems to screen for proliferation required genes in other organisms as well as to screen for antimicrobial agents.
申请公布号
WO0044906(A2)
申请公布日期
2000.08.03
申请号
WO2000US02200
申请日期
2000.01.27
申请人
ELITRA PHARMACEUTICALS, INC.
发明人
ZYSKIND, JUDITH;OHLSEN, KARI, L.;TRAWICK, JOHN;FORSYTH, R., ALLYN;FROELICH, JAMIE, M.;CARR, GRANT, J.;YAMAMOTO, ROBERT, T.;XU, H., HOWARD