发明名称 |
Novel tricyclic steroid analogs. |
摘要 |
Novel tricyclic steroid analogs are disclosed which are 1H-benz[e]indene dodecahydro compounds that are useful for enhancing GABA-induced chloride currents at the GABA receptor/chloride ionophore complex and can be represented by the following structural formulas: <CHEM> wherein R1 = H or C1-C4 alkyl or fluoroalkyl; R2 = H or C1-C4 alkyl or fluoroalkyl, in which R1 and R2 can be the same or different; R3 = H or CH3; R4 = H or CH3, in which R3 and R4 can be the same or different; R5 = H; R6 = H; R5,R6 = =O(carbonyl); R7 = H; R8 = a hydrogen bond accepting group. R7,R8 = =O(carbonyl); and R' = an ester group. |
申请公布号 |
EP0548824(A1) |
申请公布日期 |
1993.06.30 |
申请号 |
EP19920121556 |
申请日期 |
1992.12.18 |
申请人 |
WASHINGTON UNIVERSITY |
发明人 |
COVEY, DOUGLAS FLOYD, MD.;HU, YUEFEI;ZORUMSKI, CHARLES FRANCIS, MD. |
分类号 |
A61K31/215;A61K31/22;A61K31/565;A61P5/24;A61P13/02;A61P15/00;A61P23/00;A61P23/02;A61P25/02;A61P25/04;A61P25/08;A61P25/20;C07C49/345;C07C49/513;C07C62/06;C07C69/00;C07C69/608;C07C215/44;C07C255/47;C07F7/18;C07J51/00 |
主分类号 |
A61K31/215 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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