3-Phenylureido-1,4-Benzodiazepinones and their use as cholecystokinin or gastrin antagonists.

摘要

Compounds of formula (I), and salts and prodrugs thereof <CHEM> wherein: R<1> is H, certain optionally substituted C1-6alkyl, or C3-7cyclocalkyl; R<2> represents a group <CHEM> wherein X is O, S or NR<8> where R<8> is H or C1-4alkyl; R<3> is C1-6alkyl, halo or NR<6>R<7>; R<4> is C1-7alkyl, C3-7cycloalkyl, C4-7cycloalkylalkyl or optionally substituted aryl; n is 0, 1, 2 or 3; are CCK and/or gastrin receptor antagonists. They and compositions thereof are useful in therapy.