发明名称 Stable pharmaceutical composition of alkaline or alkaline earth 5-methyl tetrahydrofolate
摘要 A method for preparing d,1-5-methyltetrahydrofolic acid and the salts thereof of the formula: <IMAGE> (I) wherein X is hydrogen, an alkaline metal or alkaline earth metal; by reduction of folic acid with sodium borohydride followed by the methylation of the tetrahydrofolic acid thus obtained with aqueous solutions of formaldehye and sodium borohydride in an inert atmosphere.
申请公布号 US5223500(A) 申请公布日期 1993.06.29
申请号 US19910814571 申请日期 1991.12.30
申请人 BIORESEARCH S.P.A. 发明人 GENNARI, FEDERICO
分类号 C07D475/04 主分类号 C07D475/04
代理机构 代理人
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