METHOD FOR INDUCING ENDOGENOUS PRODUCTION OF TISSUE PLASMINOGEN ACTIVATOR (TPA)

摘要

A method for achieving elevated circulating plasmin levels and thus causing the dissolution of blood clots is disclosed. This method is particularly suited for the treatment of myocardial infarctions and other clotting disorders. This method involves in two phases the elevation of endogenous, circulating tissue plasminogen activator (tPA) levels through the administration of basic placenta angiogenic factor (PAF). In the first phase, a relatively high circulating concentration of basic PAF effects the release of tPA from sites in the vascular bed into the circulation. In the second phase, lower circulating concentrations are maintained for a period of time necessary to induce the synthesis and secretion of tPA. This induction will elevate the circulating concentrations of tPA, thus causing increases in the circulating levels of plasmin, an enzyme capable of dissolving blood clots. A method for accomplishing similar purposes is also disclosed which involves the administration of basic PAF in conjunction with heparin as the active ingredients in a pharmaceutical preparation.