ANTI-HUMAN IGE MONOCLONAL ANTIBODIES

摘要

Monoclonal antibodies specifically bind to human immunoglobulin E (IgE) and are characterized by the following properties. ? Molecular weight of approximately 150,000 determined by SDS-polyacrylamide gel electrophoresis (non-reduced state). ? Bind to human IgE-producing B cells. ? Recognize IgE bound to human or canine cell having Fc.epsilon. receptor. ? Antibodies having one of sequences No. 1 to 4 in the sequence list of N-terminal amino acid of L-chain. The antibodies bind specifically to IgE and are useful for the treatment of allergy and other medicines. 29