PHARMACEUTICAL COMPOSITIONS

摘要

Compounds of formula (I) in which the dotted line indicates the optional presence of a double bond joining the 6 and 7 positions, A is a divalent group having a chain of at least four atoms joining the oxy group and the group BX, which group A is an aliphatic hydrocarbon group or such a group in which there is replacement by one or more groups selected from formula (1) and phenylene, wherein R is hydrogen or an alkyl group and R' and R'' are the same or different alkyl groups, of one or more carbon atoms, excluding (a) replacement of that carbon atom attached to the group B, (b) replacement of both of any two carbon atoms which are joined either directly or through a single further carbon atom, and, except in the case of the replacement groups (2) and (3), (c) replacement of that carbon atom attached to the oxy group; (B) is selected from formula (4), -COO- and -OCO-, wherein R or each R separately is hydrogen or an alkyl group, X is a sugar residue and Y is hydrogen or an alkyl, alkenyl or alkynyl group, the compound (I) optionally being in the form of a physiologically acceptable ester and/or of a physiologically acceptable salt where appropriate are of value in therapy, for example in the treatment of breast cancer.