COMPOUNDS AND COMPOSITIONS FOR TREATING HIV INFECTIONS

摘要

The use of a compound respresented by formula (I) in the manufacture of a medicament for treating a mammal infected with human immunodeficiency virus, acquired immune deficiency syndrome caused by human immunodeficiency virus or acquired immunodeficiency syndrome-related complex caused by immunodeficiency virus, and stereochemical isomers and pharmaceutically acceptable salts thereof. In formula (I), W = (C1-C5) alkyl, NHR3 or OR1; B = two hydrogens, a double bond, >O, or >S; Q = R3 or AA; Z = NHR3, OR1 or AA; R1 = H, or (C1-C5) alkyl; R2 = H, CH3, -(CH2)sNHR3 or -(CH2)sAA; R3 = H or (C1-C5) alkyl or (C1-C6); alkanoyl n = 1 to 3; s = 0 to 3; q = 0 or 1; AA = a natural or unnatural-(L)- amino acid moiety; the asterisk (*) carbon atom indicate an asymmetric center; and the wavy line represents a single bond to place the (1) moiety in the cis- or trans-configuration relative to the (2) moiety except when B is two hydrogens; with the proviso that in formula (I) when B = >O, n = q = 1, W = NH2, R2 = R1 = R3 = H, Z = OH and the wavy line has the trans-configuration, then Q NOTEQUAL CO-CH(NH2)CH3.