| 摘要 |
<p>A sustained-released bactericidal cannula (4) or catheter for residence within a portion of a human body through which aqueous biological fluids can pass. The tube has polymeric matrix and antibacterial agent residing within at least a portion of the polymeric matrix. The polymeric matrix includes cured silicon rubber and the antibacterial agent is a finely divided nitrofuran compound. The preferred nitrofuran compound is soluble in water and effective to prevent proliferation of certain bacteria immediately adjacent to the catheter in an otherwise growth supporting aqueous environment when dissolved in the aqueous environment to the limit of its solubility therein at 37 °C. The solubility of the nitrofuran compound is preferably about 0.2 % by weight or less at a pH of about 6 and a temperature of about 25 °C. At least a finite portion of the polymeric matrix proximate the outer surface includes an amount of from about 10 to about 60 % by weight of the nitrofuran compound.</p> |
