A PROCESS FOR THE PREPARATION OF A SOLID DISPERSION
摘要
A novel solid pharmaceutical dispersion that improves the bioavailability of poorly water soluble drugs is produced by combining the drug with a polymer carrier such as polyvinylpyrrolidone. The drug is combined with the carrier without the need for using organic solvents or melting temperatures (fusion) through the use of a transition compound such as polyethylene glycol which partially solubilizes the drug and/or plasticizes the polymer.
申请公布号
WO9311749(A1)
申请公布日期
1993.06.24
申请号
WO1992US09989
申请日期
1992.11.18
申请人
WARNER-LAMBERT COMPANY
发明人
GHEBRE-SELLASSIE, ISAAC;REISCH, ROBERT, JR.;PARIKH, RITEN;FAWZI, MAHDI, B.;NESBITT, RUSSELL, U.