CONTROLLING GROWTH OF FILAMENTOUS MICROORGANISMS

摘要

A process for the cultivation in continuous culture of a filamentous microorganism in a culture medium to which are sup- plied sources of carbon and other appropriate nutrients. The carbon or anoth er nutrient source is supplied in an amount limiting to the growth of the culture and constitutes a limiting nutrient thereto. Th e development of an unwanted variant of the filamen- tous microorganism is restricted or delayed by supplying a first nutrient source to the culture as a limiting nutrient, and thus changing the nutrient supply to the culture in a manner such that a second nutrient source replaces the first nutrient source as the limiting nutrient: