BICYCLE-POLYAZAMACROCYCLOCARBOXYLIC ACID COMPLEXES, CONJUGATES, PREPARATION AND USE AS CONTRAST AGENTS

摘要

Complexes of bicyclopolyazamacrocyclocarboxylic acid with Gd, Mn or Fe ions are disclosed. The complexes can be covalently attached to a biologically active molecule, e.g. an antibody or antibody fragment, to form conjugates. The complexes and conjugates are useful as contrast agents for diagnostic purposes. Processes for preparing both the complex and conjugate are disclosed.