| 发明名称 |
Inhibitors of farnesyl protein transferase. |
| 摘要 |
<p>This invention relates to pharmaceutical compounds of structural formulae (I) and (II): <CHEM> and compositions and methods of treatment utilizing these compounds to inhibit farnesyl protein transferase and farnesylation of the oncogene protein Ras.</p> |
| 申请公布号 |
EP0547671(A2) |
申请公布日期 |
1993.06.23 |
| 申请号 |
EP19920203808 |
申请日期 |
1992.12.08 |
| 申请人 |
MERCK & CO. INC. |
发明人 |
SINGH, SHEO BUX;BILLS, GERALD F.;LINGHAM, RUSSELL B.;SILVERMAN, KEITH C.;ZINK, DEBORAH L. |
| 分类号 |
C07C57/155;A61K31/19;A61K31/23;A61P35/00;A61P43/00;C07C57/13;C07C69/347;C07C69/602;C12N9/99;C12P7/26;C12P7/44;C12P17/04;C12R1/01 |
主分类号 |
C07C57/155 |
| 代理机构 |
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代理人 |
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| 主权项 |
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| 地址 |
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