TUMOUR-BINDING PROTEIN COMPRISING A PHOSPHOKINASE PEPTIDE SUBSTRATE

摘要

A structurally modified protein is provided that will bind to a tumour-associated structure wherein the amino group in at least one basic amino acid in the binding protein is structurally modified to convert the amino group, -NH2, to the grouping NH-CO-X-NHR in which R is H or an amino protecting group and the grouping -CO-X-NHR is the residue of a peptide of the formula NHR-X-COOH capable of acting as a substrate for a phosphokinase. The modified protein may be radiolabelled.