BONE DISEASE-PREVENTING AND TREATING AGENT CONTAINING DIPEPTIDE AS ACTIVE INGREDIENT

摘要

PURPOSE:To provide the subject treating agent containing a specific dipeptide as an active ingredient, having an excellent therapeutic activity, and useful for osteoporosis, malignant hypercalcemia, bone Paget's disease, etc. CONSTITUTION:The objective treating agent contains a compound of the formula [R<1> is 2-10C acyl, 4-15C alkyloxycarbonyl, (substituted)benzyloxycarbony], etc.; R<2> is H; R<1> and R<2> together form a phthaloyl; R<3> is isobutyl, n-butyl, isopropyl; R<4> is n-butyl] as an active ingredient. The treating agent is preferably orally or parenterally administered usually at a daily dose of 0.1-1000mg/kg once or divided into two portions for an adult.