20-METHYL-SUBSTITUIERTE VITAMIN D-DERIVATE

摘要

New 20-methyl-substituted vitamin D derivates have general formula (I), in which R<1> is a hydrogen atom, a hydroxyl group or an alkanoyloxyl group with 1 to 12 carbon atoms or a benzoyloxyl group, R<2> is a hydrogen atom or an alkanoyl group with 1 to 12 carbon atoms or a benzoyl group; and R<3> is saturated or unsaturated, straight-chain or branched-chain hydrocarbon residue with up to 18 C atoms, possibly interrupted and/or substituted by one or several carbocyclic structures (C3-10-cycloalkyl or cycloakenyl residues, the latter having up to 2 double bonds), possibly substituted by one or several hydroxyl, oxo, amino groups and/or by one or several halogen atoms, possibly having one or several oxygen, sulphur and/or nitrogen (as (a)) atoms as chaining members in the hydrocarbon residue. Also disclosed is a process for preparing the same. These new compounds have a strongly improved induction of cell differentiation (HL-60), with respect to calcitriol, and are suitable for preparing medicaments.