| 摘要 |
<p>Antisense oligonucleotides, characterized by the fact that they are 2 min -deoxy-2 min -C-hydrocarbyl oligonucleotides with configuration 2 min R or 2 min S and that they have the following general formula (1): <CHEM> wherein n is an integer comprised between 0 and 200; R1 represents hydrocarbyl residues, such as alkyl, alkenyl and aralkyl, which are substituted at least once by groups possessing functions; B represents a mono or polynuclear heterocyclic base; R2 and R3 represent, independently from each other, heteroatom optionally bonded to hydrogen, hydrogen, or residues R1, optionally bonded to phosphor by heteroatom; and R8 represents heteroatom optionally bonded to hydrogen, hydrogen or residues R1 optionally bonded to carbon by heteroatom.</p> |
