发明名称 |
NEW COMPOUND WF 2015 A AND B, PRODUCTION THEREOF AND USE THEREOF |
摘要 |
<p>New compounds, designated WF 2015 A and B, are disclosed and which have the physicochemical characteristics described herein, are the following: (1) For WF 2015 A a) Molecular weight : 410 [FAB-MS : m/z 411 (M+H)] b) Elemental analysis : C 64.55; H 8.06; O 27.39 (by difference) c) Optical rotation: [ alpha ]23_D = -52 DEG (C=1.0, CH3OH) (2) For WF 2015 B : a) Molecular weight : 447 [FAB-MS : m/z 469 (M+Na)] b) Elemental analysis : C 58.03; H 7.94; Cl 7.31; O 26.72 (by difference) c) Optical rotatation : [ alpha ]23_D - 248 DEG (C=2.0, CHCl3) A process for producing these compounds by culturing a WF 2015 A and/or WF 2015 B producing strain belonging to the genus Scolecobasidium in a nutrient medium is also provided. The compounds WF 2015 A and B have immunosuppressing and anti-tumour activities, and pharmaceutical compositions comprising these compounds are described.</p> |
申请公布号 |
EP0314401(B1) |
申请公布日期 |
1993.06.16 |
申请号 |
EP19880309914 |
申请日期 |
1988.10.21 |
申请人 |
FUJISAWA PHARMACEUTICAL CO., LTD. |
发明人 |
OTSUKA, TAKANAO;SHIBATA, TOSHIHIRO;TERANO, HIROSHI;TSURUMI, YASUHISA;OKUHARA, MASAKUNI |
分类号 |
A61K35/74;A61K36/06;A61P35/00;C07G11/00;C12N1/14;C12P1/02;C12R1/645 |
主分类号 |
A61K35/74 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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