| 摘要 |
Compounds of general formula (I) [(am)2 Pt H2N-R Cl]<+> Cl<-> (HCl)n (H2O)m wherein: am is an amino monodentate ligand selected from the group consisting of NH3, straight or branched C1-C5 alkylamine, straight or branched C1-C3 dialkylamine, cyclopropylamine, cyclopentylamine, cyclohexylamine; or both am groups, taken together, from a bidentate amino ligand selected from the group consisting of a C2-C8 alkyl-1,2-diamine or a straight or cyclic C3-C8 alkyl-1,3-diamine; R is a group of formula p-NH2-C6H4-CO-X-(CH2)2-NRaRb where X is selected from the group consisting of O, NH and CH2, Ra and Rb, which are the same or different, are each a straight or branched C1-C4 alkyl and n and m, independently each other, are 0 or 1. Said complexes have antitumor activity. |
