FACTOR X-DERIVED POLYPEPTIDES AND ANTI-PEPTIDE ANTIBODIES, SYSTEMS AND THERAPEUTIC METHODS FOR INHIBITING INFLAMMATION

摘要

The present invention describes Factor X-derived polypeptides and anti-polypeptide antibodies, and compositions thereof, capable of inhibiting Factor X binding to cells bearing the Mac-1 receptor, such as monocytes and macrophages, and thereby inhibit Mac-1 mediated procoagulant activity and associated inflammatory processes. Methods of inhibiting Mac-1-mediated inflammation in patients using the Factor X-derived polypeptides or antibodies. Also described are methods of inhibiting the interaction of leukocytes with vascular endothelium thereby regulating the consequent hemostatic, angiogenic, immunoproliferative and extravasational responses.