PROCESS FOR THE PREPARATION OF PHARMACEUTICALLY ACTIVE THIAZOLIDINE OR OXAZOLIDINE COMPOUNDS BY A YEAST REDUCTASE

摘要

A process for preparing a compound of formula (I): or a tautomeric form thereof and/or a pharmaceutically acceptable salt thereof and/or a pharmaceutically acceptable solvate thereof, wherein: T represents a substituted or unsubstituted aryl group and T<1> is O or S; which process comprises, treating a compound of formula (II): or a tautomeric form thereof and/or a salt thereof and/or a solvate thereof, wherein T and T<1> are as defined in relation to formula (I), with a microbial reductase obtained from an appropriate red yeast; and thereafter, as required, preparing a pharmaceutically acceptable salt and/or a pharmaceutically acceptable solvate of the compound of formula (I) or a tautomeric form thereof: compounds prepared by such a process and the use of such compounds in medicine