Anxiolytic drug

摘要

Disclosed herein are anxiolytic drugs containing as an active ingredient a piperazine derivative represented by the following general formula (I): <IMAGE> (I) wherein m represents an integer from 2 to 4, X represents <IMAGE> <IMAGE> Ar represents a pyridyl group, a pyrimidinyl group, or a phenyl group which may be substituted with halogen atom, trifluoromethyl group, alkoxy group or alkyl group, and R1, R2 and R3 which may be identical or different represent lower alkoxy groups, or R3 is a hydrogen atom and R1 when taken together with R2 forms <IMAGE> (n=1, 2 or 3); and its acid addition salt. The anxiolytic drugs disclosed herein have the high binding capacities to 5-HT1A receptor which is one of the receptors for 5-hydroxytryptamine (5-HT), thereby exerting anxiolytic effects.